FEATURES

FAMILY

DESCRIPTION

Also known as NRG3_HUMAN, NRG3. Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Interacts with ERBB4.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NRG3

Pro-neuregulin-3, membrane-bound isoform

NRG3

Molecular Synopsis