FEATURES

FAMILY

DESCRIPTION

Also known as TPM4_HUMAN, TPM4. Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TPM4

Tropomyosin alpha-4 chain

TPM4

Molecular Synopsis