FEATURES

DESCRIPTION

Also known as PI42B_HUMAN, PIP4K2B, PIP5K2B. Participates in the biosynthesis of phosphatidylinositol 4, 5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4, 5)P2 synthesis and insulin-dependent conversion to PtdIns(3, 4, 5)P3 (PubMed:31091439). Homodimer. Binds TNFRSF1A (PubMed:9038203). Interacts with PIP4K2A; the interaction suppresses ubiquitination by the SPOP/CUL3 complex (PubMed:20583997).

Also known as PI42B_HUMAN, PIP4K2B, PIP5K2B. Participates in the biosynthesis of phosphatidylinositol 4, 5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ...

EXTERNAL LINKS

PIP4K2B

Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

PIP4K2B

Molecular Synopsis