FEATURES

FAMILY

DESCRIPTION

Also known as TOP2B_HUMAN, TOP2B. Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. Homodimer (PubMed:21778401). Interacts with KIAA1210 (By similarity). Interacts with PLSCR1 (PubMed:19690332).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TOP2B

DNA topoisomerase 2-beta

TOP2B

Molecular Synopsis