FEATURES

FAMILY

DESCRIPTION

Also known as CREM_HUMAN, CREM. Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550)., May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. Binds DNA as a dimer. Interacts with FHL5 (By similarity). Interacts with CDC34 (PubMed:10373550). May interact with TSSK4 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CREM

cAMP-responsive element modulator

CREM

Molecular Synopsis