FEATURES

FAMILY

DESCRIPTION

Also known as TLE2_HUMAN, TLE2. Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TLE2

Transducin-like enhancer protein 2

TLE2

Molecular Synopsis