FEATURES

FAMILY

DESCRIPTION

Also known as TLE4_HUMAN, TLE4, GRG4, KIAA1261. Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). Homooligomer and heterooligomer with other family members. Interacts with PAX5 (By similarity). Interacts with LEF1, TCF7, TCF7L1 and TCF7L2 (By similarity). Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression (By similarity). Interacts with SIX3 and SIX6 (By similarity). Interacts with PAX2 (PubMed:24676634). Interacts with TLE1 (By similarity).

EXTERNAL LINKS

TLE4

Transducin-like enhancer protein 4

TLE4

Molecular Synopsis