FEATURES

FAMILY

FMN-dependent alpha-hydroxy acid dehydrogenase family

DESCRIPTION

Also known as HAOX2_RAT, Hao2, Hao3, Haox2. Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate, 2-hydroxyoctanoate, 2-hydroxyhexanoate and 2-hydroxybutanoate, to the correspondong 2-oxoacids (PubMed:15683236, PubMed:3061453, PubMed:8508789). Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (By similarity). Can also use mandelate as substrate (PubMed:3061453). Active in vitro with the artificial electron acceptor 2, 6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:15683236, PubMed:3061453, PubMed:8508789). Homotetramer (PubMed:8508789). Could also form homooctamer.

Also known as HAOX2_RAT, Hao2, Hao3, Haox2. Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate, 2-hydroxyoctanoate, 2-hydroxyhexanoate and 2 ...

EXTERNAL LINKS

Hao2

2-Hydroxyacid oxidase 2

Hao2

Molecular Synopsis