FEATURES

DESCRIPTION

Also known as MFGM_HUMAN, MFGE8. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction., Main constituent of aortic medial amyloid.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MFGE8

Lactadherin

MFGE8

Molecular Synopsis