FEATURES

FAMILY

DESCRIPTION

Also known as ACSM1_HUMAN, ACSM1, BUCS1, LAE, MACS1. Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity). Monomer.

Also known as ACSM1_HUMAN, ACSM1, BUCS1, LAE, MACS1. Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065). Capable of a ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACSM1

Acyl-coenzyme A synthetase ACSM1, mitochondrial

ACSM1

Molecular Synopsis