FEATURES

DESCRIPTION

Also known as FP100_HUMAN, FAAP100, C17orf70. Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and FAAP100. Forms a subcomplex with FANCB and FANCL.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FAAP100

Fanconi anemia core complex-associated protein 100

FAAP100

Molecular Synopsis