FEATURES

FAMILY

SLC13A/DASS transporter (TC 2.A.47) family

DESCRIPTION

Also known as S13A2_HUMAN, SLC13A2, NADC1, SDCT1. Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:9668069, PubMed:8967342). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:8967342, PubMed:9668069, PubMed:10894787). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity).

Also known as S13A2_HUMAN, SLC13A2, NADC1, SDCT1. Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumara ...

EXTERNAL LINKS

SLC13A2

Solute carrier family 13 member 2

SLC13A2

Molecular Synopsis