FEATURES

FAMILY

DESCRIPTION

Also known as MPP3_HUMAN, MPP3, DLG3. Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (PubMed:24503895). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions (By similarity). Interacts with HTR2C; this interaction stabilizes the receptor at the plasma membrane and prevents the desensitization of the HTR2C receptor-mediated calcium response (By similarity). Interacts with HTR2A (By similarity). Interacts with HTR4 (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus)Interacts (via PDZ domain) with CADM1; this interaction connects CADM1 with DLG1 (PubMed:24503895). Interacts (via Guanylate kinase-like domain) with PALS1 (PubMed:16519681). Interacts with DLG1 (via N-terminus); this interaction connects CADM1 with DLG1 and links CADM1 with the regulatory subunit of phosphoinositide-3-kinase (PI3K) by forming a multiprotein complex and participates in cell spreading (PubMed:24503895, PubMed:16519681).

EXTERNAL LINKS

MPP3

MAGUK p55 subfamily member 3

MPP3

Molecular Synopsis