FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE3B_HUMAN, PDE3B. Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). Homodimer (PubMed:15147193). Interacts with PIK3CG; regulates PDE3B activity and thereby cAMP levels in cells (By similarity). Interacts with RAPGEF3 and PIK3R6; form a signaling complex that regulates phosphatidylinositol 3-kinase gamma in angiogenesis (PubMed:21393242).

EXTERNAL LINKS

PDE3B

cGMP-inhibited 3', 5'-cyclic phosphodiesterase 3B

PDE3B

Molecular Synopsis