FEATURES

DESCRIPTION

Also known as FKBP5_HUMAN, FKBP5, AIG6, FKBP51. Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production (PubMed:26101251, PubMed:31434731). Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place (By similarity). Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (PubMed:7693698). Interacts with NR3C1 (By similarity). Interacts with Akt/AKT1 and PHLPP1; enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). Interacts with IFI44L; this interaction modulates the kinase activity of IKBKB and IKBKE (PubMed:31434731). Interacts with IKBKB and IKBKE (PubMed:26101251, PubMed:31434731).

EXTERNAL LINKS

FKBP5

Peptidyl-prolyl cis-trans isomerase FKBP5

FKBP5

Molecular Synopsis