FEATURES

FAMILY

DESCRIPTION

Also known as NOG2_HUMAN, GNL2, NGP1. GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). Interacts with LYAR and RPL23A (PubMed:26203195). Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha (PubMed:21495629).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GNL2

Nucleolar GTP-binding protein 2

GNL2

Molecular Synopsis