FEATURES

DESCRIPTION

Also known as TRI29_HUMAN, TRIM29, ATDC. Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. Interacts with VIM and HINT1 (PubMed:7644499). Interacts with IKBKG/NEMO (PubMed:27695001). Interacts with STING1 (PubMed:29038422).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRIM29

Tripartite motif-containing protein 29

TRIM29

Molecular Synopsis