FEATURES

FAMILY

DESCRIPTION

Also known as ITPR3_HUMAN, ITPR3. Receptor for inositol 1, 4, 5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Homotetramer. Interacts with TRPC1, TRPC3 and TRPC4. Interacts with TRPV4 (PubMed:18826956). Interacts with SIGMAR1 (By similarity). Interacts with PML and AKT1 (By similarity). Interacts with IRAG2 (via coiled-coil domain) (By similarity). Interacts with CABP1 (PubMed:12032348). Interacts with TMBIM4/LFG4 (PubMed:19553469). Interacts with CEMIP (PubMed:23936024). Interacts with TESPA1 (By similarity). Interacts with TMEM203 (PubMed:25996873). Interacts with BOK; regulates ITPR3 expression (By similarity). Interacts with BCL2L10 (PubMed:27995898).

EXTERNAL LINKS

ITPR3

Inositol 1, 4, 5-trisphosphate receptor type 3

ITPR3

Molecular Synopsis