FEATURES

FAMILY

DESCRIPTION

Also known as ITIH4_HUMAN, ITIH4, IHRP, ITIHL1, PK120. Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain); this interaction protects ITIH4 against cleavage by kallikrein in vitro.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ITIH4

Inter-alpha-trypsin inhibitor heavy chain H4

ITIH4

Molecular Synopsis