FEATURES

FAMILY

DESCRIPTION

Also known as GRM7_HUMAN, GRM7, GPRC1G, MGLUR7. G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604). Homodimer (PubMed:33476302, PubMed:33500274). Interacts with PICK1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GRM7

Metabotropic glutamate receptor 7

GRM7

Molecular Synopsis