FEATURES

FAMILY

DESCRIPTION

Also known as HAPR1_HUMAN, HAPSTR1, C16orf72, TAPR1. Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365). Homooligomer (PubMed:35776542). Heterooligomer with HAPSTR2; the interaction is direct and stabilizes HAPSTR1 (PubMed:36631436). Interacts with HUWE1 (PubMed:35776542).

EXTERNAL LINKS

HAPSTR1

HUWE1-associated protein modifying stress responses 1

HAPSTR1

Molecular Synopsis