FEATURES

FAMILY

DESCRIPTION

Also known as CND1_HUMAN, NCAPD2, CAPD2, CNAP1, KIAA0159. Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.

Also known as CND1_HUMAN, NCAPD2, CAPD2, CNAP1, KIAA0159. Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromos ...

EXTERNAL LINKS

NCAPD2

Condensin complex subunit 1

NCAPD2

Molecular Synopsis