FEATURES

FAMILY

DESCRIPTION

Also known as ACOX1_HUMAN, ACOX1, ACOX. Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (PubMed:7876265, PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382). Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) (PubMed:7876265, PubMed:17458872, PubMed:17603022)., Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro., Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. Homodimer (PubMed:32169171). Interacts with LONP2 (PubMed:18281296).

EXTERNAL LINKS

ACOX1

Peroxisomal acyl-coenzyme A oxidase 1

ACOX1

Molecular Synopsis