FEATURES

FAMILY

DESCRIPTION

Also known as PTPRR_HUMAN, PTPRR, ECPTP, PTPRQ. Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). Interacts with MAPKs.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTPRR

Receptor-type tyrosine-protein phosphatase R

PTPRR

Molecular Synopsis