FEATURES

FAMILY

DESCRIPTION

Also known as NSDHL_HUMAN, NSDHL, H105E3. Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Also plays a role in the regulation of the endocytic trafficking of EGFR (By similarity). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NSDHL

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

NSDHL

Molecular Synopsis