FEATURES

FAMILY

class-I pyridine nucleotide-disulfide oxidoreductase family

DESCRIPTION

Also known as TRXR1_HUMAN, TXNRD1, GRIM12, KDRF. Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437)., Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions., Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2., Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665). Homodimer (PubMed:17512005, PubMed:8577704). Interacts with HERC5.

EXTERNAL LINKS

TXNRD1

Thioredoxin reductase 1, cytoplasmic

TXNRD1

Molecular Synopsis