FEATURES

FAMILY

krueppel C2H2-type zinc-finger protein family

DESCRIPTION

Also known as ZN827_HUMAN, ZNF827. As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, HNRNPK and HNRNPL (PubMed:33174841). Interacts with the nucleosome remodeling and histone deacetylase/NuRD complex (PubMed:25150861). Interacts with RBBP4; the interaction is direct and recruits RBBP4, a component of the NuRD complex, to telomeres (PubMed:30045876).

EXTERNAL LINKS

ZNF827

Zinc finger protein 827

ZNF827

Molecular Synopsis