FEATURES

DESCRIPTION

Also known as INSC_HUMAN, INSC. May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity). Interacts with ALS2CR19/PAR3B and F2RL2/PAR3 (PubMed:16458856). Interacts with GPSM1/AGS3 and GPSM2/LGN (via TPR repeat region) (PubMed:16458856, PubMed:22074847). Identified in a complex with GPSM2 and F2RL2 (PubMed:16458856).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

INSC

Protein inscuteable homolog

INSC

Molecular Synopsis