FEATURES

FAMILY

DESCRIPTION

Also known as PDS5A_HUMAN, PDS5A, KIAA0648, PDS5. Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Interacts with the cohesin complex. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PDS5A

Sister chromatid cohesion protein PDS5 homolog A

PDS5A

Molecular Synopsis