FEATURES

DESCRIPTION

Also known as TM266_HUMAN, TMEM266, C15orf27, HVRP1. Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529). Homodimer; disulfide-linked.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TMEM266

Transmembrane protein 266

TMEM266

Molecular Synopsis