FEATURES

FAMILY

DESCRIPTION

Also known as SPKAP_HUMAN, SPHKAP, KIAA1678, SKIP. Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. Interacts (via the PKA-RII subunit binding domain) with the RI subunit of PKA. Interacts with SPHK1; the interaction greatly reduces SPHK1 activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SPHKAP

A-kinase anchor protein SPHKAP

SPHKAP

Molecular Synopsis