FEATURES

FAMILY

DESCRIPTION

Also known as PWP3A_HUMAN, PWWP3A, EXPAND1, MUM1. Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. Interacts with TP53BP1 (via BRCT domain); the interaction is not dependent on its phosphorylation status. Binds nucleosomes. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3) (in vitro).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PWWP3A

PWWP domain-containing DNA repair factor 3A

PWWP3A

Molecular Synopsis