FEATURES

FAMILY

DESCRIPTION

Also known as MGT5B_HUMAN, MGAT5B, KIAA2008. Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1, 2-Man-alpha on both the alpha1, 3- and alpha1, 6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1, 2-Man-alpha1-Ser/Thr moiety, forming a 2, 6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.

EXTERNAL LINKS

MGAT5B

Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

MGAT5B

Molecular Synopsis