FEATURES

FAMILY

monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

DESCRIPTION

Also known as SL9C1_HUMAN, SLC9C1, SLC9A10. Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). Interacts with soluble adenylyl cyclase (sAC).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC9C1

Sodium/hydrogen exchanger 10

SLC9C1

Molecular Synopsis