FEATURES

FAMILY

DESCRIPTION

Also known as C27C1_HUMAN, CYP27C1. A cytochrome P450 monooxygenase that catalyzes the 3, 4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3, 4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).

EXTERNAL LINKS

CYP27C1

Cytochrome P450 27C1

CYP27C1

Molecular Synopsis