FEATURES

FAMILY

DESCRIPTION

Also known as MPPE1_HUMAN, MPPE1, PGAP5. Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins. Interacts with GPI-anchor proteins. Interacts with TMED10.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MPPE1

Metallophosphoesterase 1

MPPE1

Molecular Synopsis