FEATURES

FAMILY

zinc-containing alcohol dehydrogenase family

DESCRIPTION

Also known as QORX_HUMAN, TP53I3, PIG3. Catalyzes the NADPH-dependent reduction of quinones (PubMed:19349281). Exhibits a low enzymatic activity with beta-naphthoquinones, with a strong preference for the ortho-quinone isomer (1, 2-beta-naphthoquinone) over the para isomer (1, 4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2, 6-dichloroindophenol (in vitro) (PubMed:19349281). Involved in the generation of reactive oxygen species (ROS) (PubMed:19349281). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TP53I3

Quinone oxidoreductase PIG3

TP53I3

Molecular Synopsis