FEATURES

FAMILY

DESCRIPTION

Also known as ACTMP_HUMAN, ACTMAP, C19orf54. Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). Interacts (via N-terminus) with PFN2 isoforms IIa and IIb; the interactions may facilitate efficient cleavage of the acetylated N-terminus of immature actin (PubMed:36173861). Interacts with PFN1 (PubMed:36173861).

EXTERNAL LINKS

ACTMAP

Actin maturation protease

ACTMAP

Molecular Synopsis