FEATURES

FAMILY

DESCRIPTION

Also known as CMPK2_HUMAN, CMPK2. May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

Also known as CMPK2_HUMAN, CMPK2. May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CMPK2

UMP-CMP kinase 2, mitochondrial

CMPK2

Molecular Synopsis