FEATURES

FAMILY

DESCRIPTION

Also known as DOC11_HUMAN, DOCK11, ZIZ2. Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. Interacts with CDC42.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DOCK11

Dedicator of cytokinesis protein 11

DOCK11

Molecular Synopsis