FEATURES

FAMILY

DESCRIPTION

Also known as COA6_HUMAN, COA6, C1orf31. Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. Interacts with COA1 (PubMed:22356826). Found in a complex with TMEM177, COX20, MT-CO2/COX2, COX18, SCO1 and SCO2 (PubMed:29154948). Interacts with MT-CO2/COX2 and SCO2 (PubMed:25959673). Interacts with SCO1 (PubMed:26160915). Interacts with COX20 in a MT-CO2/COX2- and COX18-dependent manner (PubMed:29154948, PubMed:28330871). Interacts with COX16 (PubMed:29381136).

EXTERNAL LINKS

COA6

Cytochrome c oxidase assembly factor 6 homolog

COA6

Molecular Synopsis