FEATURES

DESCRIPTION

Also known as RNFT1_HUMAN, RNFT1. E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNFT1

E3 ubiquitin-protein ligase RNFT1

RNFT1

Molecular Synopsis