FEATURES

FAMILY

DESCRIPTION

Also known as TM201_HUMAN, TMEM201, NET5, SAMP1. Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860)., May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). Isoform 2 interacts with EMD (PubMed:21610090). Interacts with SUN2 and LMNA (By similarity). May bind to Ran GTPase; has a greater affinity for Ran-GTP over Ran-GDP.

EXTERNAL LINKS

TMEM201

Transmembrane protein 201

TMEM201

Molecular Synopsis