FEATURES

DESCRIPTION

Also known as DEP1A_HUMAN, DEPDC1, DEPDC1A. May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Isoform 2 and isoform 5 can form homodimers and heterodimers. Interacts with ZNF224.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DEPDC1

DEP domain-containing protein 1A

DEPDC1

Molecular Synopsis