FEATURES

FAMILY

DESCRIPTION

Also known as CE162_HUMAN, CEP162, C6orf84, KIAA1009, QN1. Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. Interacts with CEP290 (PubMed:23644468). Interacts with CPNE4 (By similarity). Interacts with alpha-tubulin (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CEP162

Centrosomal protein of 162 kDa

CEP162

Molecular Synopsis