FEATURES

DESCRIPTION

Also known as BIG3_HUMAN, ARFGEF3, BIG3, C6orf92, KIAA1244. Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). Interacts with PHB2.

Also known as BIG3_HUMAN, ARFGEF3, BIG3, C6orf92, KIAA1244. Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ARFGEF3

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

ARFGEF3

Molecular Synopsis