FEATURES

FAMILY

DESCRIPTION

Also known as GKAP1_HUMAN, GKAP1, GKAP42. Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. Interacts with PRKG1 and IRS1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GKAP1

G kinase-anchoring protein 1

GKAP1

Molecular Synopsis