FEATURES

DESCRIPTION

Also known as RN220_HUMAN, RNF220, C1orf164. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658, PubMed:33964137). Plays a critical role in the regulation of nuclear lamina (PubMed:33964137). Interacts with SIN3B (By similarity). Interacts with CTNNB1 (via Armadillo repeats 2-8) (PubMed:25266658, PubMed:33964137). Interacts with USP7 (via MATH domain) (PubMed:25266658).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNF220

E3 ubiquitin-protein ligase RNF220

RNF220

Molecular Synopsis