FEATURES

FAMILY

DESCRIPTION

Also known as HHAT_HUMAN, HHAT, MART2, SKI1. Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (PubMed:18534984, PubMed:31875564, PubMed:24784881). It also catalyzes N-terminal palmitoylation of DHH (PubMed:24784881). Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs (PubMed:31875564). It is an essential factor for proper embryonic development and testicular organogenesis (PubMed:24784881).

Also known as HHAT_HUMAN, HHAT, MART2, SKI1. Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (PubMed:18534984, PubMed:31875564, PubM ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HHAT

Protein-cysteine N-palmitoyltransferase HHAT

HHAT

Molecular Synopsis