FEATURES

DESCRIPTION

Also known as C1QL3_HUMAN, C1QL3, CTRP13. May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production (By similarity). Forms homooligomers. Interacts with ADGRB3. Interacts with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

C1QL3

Complement C1q-like protein 3

C1QL3

Molecular Synopsis